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光热生物数据库——表达差异-治疗反应

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输入示例:MKI67 LUAD(MKI67为基因名称;LUAD为肿瘤名。)
Example:MKI67 LUAD(MKI67 refers to gene name;LUAD refers to cancer name.)
如下22个肿瘤有第一次治疗结局:ACC BLCA CESC COAD DLBC ESCA HNSC KICH KIRC KIRP LGG LUAD LUSC OV PAAD PCPG PRAD READ STAD TGCT UCEC UCS
Twenty-two cancers have the treatment outcome during the first treatment course:ACC BLCA CESC COAD DLBC ESCA HNSC KICH KIRC KIRP LGG LUAD LUSC OV PAAD PCPG PRAD READ STAD TGCT UCEC UCS
图示:基因在第一疗程治疗结局的表达差异
Figure:Differential gene expression at the end of the first course of treatment

说明:TCGA-LUAD队列中基因在各个分期的表达差异。 方框的上端和下端表示值的四分位数范围。方框中的线表示中值。 Kruskal-Wallis Rank Sum Test比较多组之间的表达量统计学差异。
Description:Differential gene expression at different stages in the TCGA-LUAD cohort. The top and bottom ends of the box represent the quartile range of values. The line in the box represents the median value. Kruskal-Wallis Rank Sum Test compares the expression levels of multiple groups.
方法:(数据同前)第一次治疗后患者具有不同的治疗响应,采用Kruskal-Wallis Rank Sum Test比较LUAD数据集中MKI67在不同响应组的的表达量统计学差异。
Methods:(Same data as before)After the first treatment, patients have different treatment responses. Kruskal-Wallis Rank Sum Test compares the MKI67 expression level in the LUAD dataset in different response groups.
结果:在进展性与稳定的疾病中,MKI67表达更高,对于部分缓解组和完全缓解组表达更低,提示MKI67高表达组对疾病的治疗反应更差。
Results:MKI67 expression is higher in progressive and stable disease and lower in partial and complete response groups, suggesting that high-MKI67 expression groups has a worse treatment response to the disease.


IP属地:安徽1楼2024-07-21 23:32回复