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光热生物数据库——生存分析-uniCox

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输入示例:MKI67 LUAD(MKI67为基因名称;LUAD为肿瘤名。)
Example:MKI67 LUAD(MKI67 refers to gene name;LUAD refers to cancer name.)
图示:4个生存期(OS,DSS,PFI和DFI)的单因素cox生存分析的meta分析
Figure:A meta-analysis of univariate cox survival analysis for 4 survival periods (OS,DSS,PFI, and DFI)

说明:生存风险比Meta分析。Meta分析中,HR(风险比例)的标准误差使用95%CI(置信区间)计算。
Description:Meta-analysis of survival hazard ratio. In the meta-analysis, the standard error of HR (hazard ratio) is calculated using 95%CI (confidence interval).
方法:采用逆方差法对单因素cox生存分析的结果进行Meta分析,以对数HR值为主要测量指标。HR值分为小于1和大于1两类(HR小于1意味着所检测的基因具有抑癌作用,而HR大于1则表明该基因具有促癌作用)。这种分类没有考虑与所研究基因相关的调节机制。在R(4.3.2版本0)中使用“Meta”包进行统计分析和可视化。
Methods:A meta-analysis of univariate Cox survival analysis results is conducted using inverse variance method, with the logarithm of the hazard ratio (HR) as the primary measurement indicator. The HR values have two categories: less than 1 and greater than 1 (an HR less than 1 indicates that the detected gene has an anti-cancer effect, while an HR greater than 1 indicates that the gene has a pro-cancer effect). This classification does not take into account the regulatory mechanisms associated with the studied gene. Statistical analysis and visualization are performed using the "Meta" package in R (version 4.3.2).
结果:MKI67与LUAD的OS,DSS及PFI相关(p<0.05),且是危险因素(HR>1),荟萃分析的结果与之一致,不同的生存期的结果存在较低的异质性。
Results:MKI67 is associated with OS, DSS and PFI of LUAD (p<0.05) and is a risk factor (HR>1), consistent with meta-analysis results with low heterogeneity across different survival periods.


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